Handlebars is a close successor to Mustache, and both can actually be used at the same time, with the ability to swap out tags where necessary. The only difference is that Handlebars is more focused on helping developers to create semantic templates, without having to involve all the confusion and time consumption. You can easily try out Handlebars yourself (there’s also an option to try Mustache on the same page) and see for yourself whether this is the type of templating engine you’re looking for.
doT.js is small, efficient, fast and lightweight templating engine that supports itself (no dependancies), and works great with Node.js and native Browser integration.
When people say Python is like writing in English, they underestimate the magnitude of that statement when it comes to Pug syntax programming. The Pug template engine (for Node.js) is literally enabling developers to write code that looks like paragraphs straight out of a book. Not only does this improve the overall code productivity, it can help to streamline the work on a project that consists of multiple team members.
When choosing the right templating engine for our projects, we should take into consideration the exact type of work we are looking to do, and how much of the project is actually going to have to be templated, and what kind of solution would work out for you individually in both long-term and short-term.